Research on Royal Jelly

Liver and biliary tract

In many clinics around the world, for many years now, the use of bee products in the treatment of the liver and bile ducts (ducts) has been used more and more intensively.

It has been known since ancient times that honey has been used with great success in the treatment of liver and bile, so it is not surprising that even today doctors increasingly recommend it to their patients along with other products from the hive - royal jelly and pollen.

The liver has multiple roles in our body, it is often called the central laboratory of the body, substances received from the whole organism are dissolved, processed and fully utilized there. The liver produces bile and excretes it in the gallbladder, from where the bile enters the intestines through the bile ducts, thus enabling the digestion of fat. It is able to break down and remove many toxins that are created in the body. The liver also serves as a reservoir of blood that it makes available when the need arises. And this is not the end of the story about the importance of the liver in the human body, and the very fact that a person cannot live without the liver tells us that the disease of this organ is always a very serious matter.

Bee products are used in the treatment of the liver primarily because they contain sugars - fruit and especially grapes, which has long been used for this purpose. Both of these sugars are characterized by easy digestibility, ie. they do not require the presence of digestive juices for decomposition, but go directly into the blood, and thus into the liver, where they are deposited in the form of glycogen, which is a store of sugar, ie. "fuel tank" for the whole organism. The liver contains a lot of glycogen, especially when it is healthy. The diseased liver loses glycogen and fat is deposited in its place and thus a "fatty liver" develops. By taking grape and fruit sugar, a material is created that builds glycogen, which suppresses harmful fats from the liver and thus regenerates the liver.

Bee products contain enzymes (diastase, invertase, catalase, etc.) whose intake is very useful when they weaken digestive functions due to liver disease. The presence of inhibin, which prevents infection, in bee products and their consumption is extremely important in the occurrence of liver and bile diseases. Also, the presence of phosphorus, potassium and many other micro and macro elements in bee products have a positive effect on the liver itself.

Due to the exceptional topicality of the problems we encounter in the treatment of liver, it is necessary to present the views of Romanian authors Ćupija A., Dragulescu N. and Tanese-Magoš Joane, who in 1976, in their work presented the results and the perspective of bee products in the treatment of chronic hepatitis.

Although the liver has an amazing ability to regenerate, it does not reduce its sensitivity to any stress (nutritional, toxic, nervous) and if they are stronger, more frequent or long-acting, there will be functional liver failure, as well as metabolic disorders of all cells and tissues in the body.

Because of all that, as Romanian medical researchers state, systemically applied bee products give extraordinary results in the treatment of chronic hepatitis. Royal jelly was used in cases of chronic hepatitis as well as in evolutionary aggressive hepatitis, which was given together with honey, after which there was an increase in body weight and development of muscle tissue, and in cases of vascular-decompensated cirrhosis, the effect of diet was increased. It was noticed that the patients tolerated the bee products well and that there were no accompanying counter-effects.

What is still very important in all this is that in hepatic diseases, pacreopathy also occurs at the same time, in which taking refined sugar and consuming more flour products disrupts carbohydrate exchange, and the use of bee products instead of these products is absolutely justified.


Chronic kidney disease is a major problem for medicine, so that in 1981 a group of Bulgarian researchers, Gergieava E. and Vasilev V. used royal jelly in the treatment of chronic renal failure (failure) of various origins in 49 patients. The treatment lasted for a month, and obvious progress was achieved in 75% of patients, who had anemia, elevated urea, creatinine and folic acid, while at the same time visibly improving their general condition

Antiparasitic action

Not many papers have been written on this topic, but despite this, it has been discovered that royal jelly is also antiparasitic. Stejskal from Venezuela proved that royal jelly works against Trypanosome cruci and dysenteric amoeba.

Kabrik H. found that royal jelly kills ciliates.

Effect of sideropenic anemia

Anemia (anemia) means the inability of erythrocytes (red blood cells) to "deliver" a sufficient amount of oxygen to the cells of the body. The causes can be multiple, and the most common is iron deficiency in the erythrocytes themselves, without which the oxygen we breathe will not bind to erythrocytes and cells will work with a lack of oxygen, which causes a number of disorders in the body.

Iron deficiency occurs due to increased need for it, insufficient food intake, decreased intestinal absorption or loss due to bleeding. Increased needs exist in childhood, adolescence, pregnancy, and lactation.

Glandular anemia (sideropenic anemia) is always a chronic disease and does not occur immediately, even after acute bleeding. According to the WHO (Iron Health Organization), iron deficiency is becoming more common in all populations and is therefore one of the leading health problems in the world today, occurring in both poor and rich countries.

Treatment of sideropenic anemia is performed with synthetic preparations of divalent iron. Despite continuous improvement, this therapy is not entirely satisfactory due to the many side effects that primarily occur due to the low rate of resorption of inorganic compounds, and the use of which requires high doses.

Royal jelly contains iron and is divalent (iron that is ingested through food is trivalent and it is reduced in the intestines to divalent which is only able to bind oxygen) and its use in anemia gives fantastic results. Due to all the above, it becomes very clear that the role of royal jelly in this disease is absolutely irreplaceable, and that no synthetic preparation can compete with it.

Regenerating properties

One of the first researches related to the examination of the effect of royal jelly on damaged cells took place in the Soviet Academy of Sciences, where the regenerating property of royal jelly was proven. Then scientists from Argentina, Lamberti R. and Korneho L. discovered that royal jelly contains gamma globulin whose role is in creating the body's defenses.

The protein group of royal jelly also contains collagen in its wide range. It was previously thought that the aging process, among other things, is most characterized by the aging of blood vessels, while today it is known that collagen also plays a major role in the aging process.

Royal jelly contains many elements that are necessary for the organism, which is why this product is considered both a nutritious and a healing agent, because it stimulates the activity of living cells. It is a natural substance that helps a living organism to overcome the action of factors that cause aging, and also affects many factors that can lead to the appearance of diseases or to be toxic. Today it can be freely said that royal jelly occupies one of the first places, on the list of therapeutic agents, which possess regenerating properties.

As a suitable model to confirm the above, we can take the effect of royal jelly on damaged cells of the pancreas, or its β-Langerhans cells (which normally produce insulin), whose damage leads to one of the most common diseases today - diabetes (see diabetes) . 

Antivirus action

Influenza, or the flu as it is popularly called, a highly infectious disorder of the upper respiratory tract, has accompanied humanity for more than 2,000 years.

The influenza virus is mainly a droplet infection that is transmitted by coughing and sneezing, infects the epithelial cells of the upper respiratory tract, and after a very short incubation time, which usually lasts 24-48 hours, the first clinical symptoms appear.

In the treatment of flu and colds, bee products have been shown to be quite successful. Thus, in 1985, in Romania, Adelina Dervič managed to prove that royal jelly destroys the influenza virus. Romanian scientists have managed to prove their research on the antiviral effect of royal jelly on a chicken embryo. Dervič A. and Petresko injected the virus culture together with royal jelly into the allantoid cavity of the chicken embryo. All tests, without exception, showed that the virus did not develop, and normal chickens hatched from those eggs.

Antibacterial ADiabetes

Damage to the pancreas, especially the ß-Langerhans islets, leads to one of the most common diseases today, diabetes. If royal jelly can regenerate pancreatic cells, blood sugar levels will drop. Patients were given doses of 30-50 mg of lyophilized royal jelly for 6 to 8 weeks. Exceptional results have been achieved since all patients have responded positively to this type of therapy. In some there were minor improvements, and in others the effects were very pronounced. These results of the research seemed so incredible that the data were not even published for a long time due to the lack of knowledge about what causes such significant effects in milk in the treatment of this serious disease. The results of this research, modern science can only confirm. Analyzing the fine structure of royal jelly proteins, with modern methods, an isolated substance that causes this effect has been proven. It is an insulin-like peptide. The effect caused by this peptide is completely similar to animal insulins. In addition to the primary insulin effect - lowering blood sugar levels, this substance is important for another reason. Namely, diabetes also has an effect on raising blood pressure. Diabetics always take some antihypertensive as well. This natural substance, as its secondary effect, regulates arterial pressure. (Dragan Panić: Royal Jelly - Belgrade, 2000)ction Scientists in many countries, both in the West and in the East, have found that royal jelly shows bacteriostatic (stops the growth of bacteria) and bactericidal (kills bacteria) properties. It is known that all bacterial species have the ability to grow and multiply on a moist, appropriate pH value, a medium that contains nutrients in certain temperature conditions. Fresh royal jelly has an acidic reaction (pH 3.6) so it creates unsuitable miles for the growth and development of bacteria.

The first observations on the antibacterial activity of royal jelly, even before the beginning of the antibiotic era, in 1939, were announced by Mc Cleskey and Melamphy, who stated that royal jelly has a bactericidal effect on some bacteria: staphylococci, intestinal bacteria and paratyphoid bacteria. At that time, it was impossible to determine the exact substances in the milk that have an antibacterial effect. Shortly afterwards, in the late 1940s, Fleming discovered a miraculous substance - an antibiotic, when the era of antibiotics began when the infection was thought to have come to an end. Unfortunately, the situation developed in a bad direction, with very wide and irrational use of antibiotics, bacteria "outwitted" people and began to develop resistance to antibiotics, which is still one of the leading problems today because strains of bacteria that are multidrug resistant (such as is MRSA-multi-resistant Staphylococcus aureus) which means that they have created resistance to almost all antibiotics and are becoming more resistant every day. This has led many to look for other, new substances that will act antibacterial.

In the search for a new drug that would enable the fight against resistant bacteria, all known substances are tested, all existing resources are checked and it is returned to bee products, including royal jelly as a substance rich in proteins. Recent research shows that future bacteriostatic substances should be sought in giant and insufficiently tested protein molecules. Tests have borne fruit, today it is known that royal jelly contains a powerful antibacterial protein called rojazalin (Fujiwara S. et al. 1990), which is another proof of how many new and untested substances are found in royal jelly. The very fact that royal jelly does not spoil no matter how long it stands, goes in favor of its antibacterial action.

A number of studies and various studies have shown that royal jelly has an antibacterial effect. We are particularly pleased that one study showed (Abd - Alla M. et al. 1995) that royal jelly has a 100% bactericidal effect on Staphylococcus aureus, a bacterium that is becoming more and more resistant to antibiotics.

Old Age

The effect of royal jelly on old, disabled people, as well as on people who have difficulty recovering after long and exhausting illnesses, was also examined. The positive effects of royal jelly as a natural anabolic are also observed in the application of all forms of weakness of the organism due to disease or old age. In these cases, royal jelly is seen to act as a natural and very effective biostimulator. For example, the famous apita therapist Luđanski (1994) describes many cases from his experience, when due to the ineffectiveness of conventional drugs and methods of treatment, using royal jelly, especially with the use of other bee products, achieved surprising effects in treating various age-related diseases and conditions. sclerotic and menopausal processes. Destrem (1956) achieved good and very good results in 70% of cases in the treatment of royal jelly (60 mg intramuscularly or 18 mg sublingually) in middle-aged and elderly patients with symptoms of premature aging and age-related weakness, in a period of one month. (Dragan Panić: Royal Jelly - Belgrade, 2000) 


The anabolic and energizing effect of royal jelly is seen not only in the sick but also in healthy people and athletes who achieve an increase in work ability and endurance. This is proved by the works of Lupačev (1963, 1976), Nikulin, Ivaškjavicene with co-authors (1989) and others. By analyzing the mechanism of increasing resistance to physical activity, Nedeljka and Golovkin (1990) found an increase in the partial pressure of oxygen in arterial blood in animals by 22%, an increase in oxygen use in tissues by 6% and an increase in lactic acid content. From these parameters, it can be concluded that it is about forcing anaerobic processes and raising energy in the body. Also, the ability of royal jelly to enhance tissue respiration and oxidative phosphorylation has been experimentally proven (Nikulin, Jakuševa, 1989). It is obvious that royal jelly has a stimulating effect on aerobic and anaerobic energy exchange. (Dragan Panić: Royal Jelly - Belgrade, 2000)


Analogous to the biological non-use of royal jelly as food for the development and growth of larvae (developing organisms), royal jelly is successfully used in prevention and therapy in children. There is a wealth of data in the literature on the high efficacy of royal jelly in sick and exhausted children. From the earlier works of Russian authors, we will cite the work of Lebedeva (1959), in which the author described the treatment with royal jelly of one-year-old children with hypotrophy.

After seven days of application of royal jelly (5 mg three times a day, intrarectally), children were observed to gain weight, improve general condition, appetite, sleep, tissue turgor, skin elasticity and subcutaneous fat. Later, other authors came to similar results. Roshal (1960) describes a positive therapeutic effect in the treatment of royal jelly in children with permanent forms of chronic eating disorder, Iljaš (1962) indicates the effectiveness of its use in eating disorders in infants.

This author emphasizes that the positive effect of royal jelly treatment is achieved in cases when previously applied and clinically accepted stimulants (blood plasma transfusion, vitamin therapy, aerotherapy, etc.) did not give positive results. There were also no side effects. Similar effects are described by Vasiljeva (1962) in the treatment of dystrophy in children and Sudakova (1962) in diseases of the locomotor system in malnourished children. High biostimulatory activity of royal jelly was determined by Fatejeva and Galst (1974) in the treatment of premature infants with hypotrophy, as well as Dešćenkina and Iljaš (1974) in the treatment of newborns with internal brain trauma.

From the above examples, it follows that the use of royal jelly to stimulate the growth and development of children's organisms, as in bees, gives positive results. (Dragan Panić: Royal Jelly - Belgrade, 2000) 

Nervous System

Under the influence of diseases, stress, chemicals and other factors, the nervous system "wears out". A large number of serious diseases are caused by irregularities of the nervous system. The task set before Russian academics in the early 60's was to find an adaptogen that can help in restitution and recovery of the damaged nervous system. The first papers on the use of royal jelly in the complex treatment of diseases of the nervous system characteristic of age were published by Vitek and Janči in 1968.

These are the most common disorders in the supply of blood to the brain without focal damage, diffuse arteriosclerosis of the brain with small foci, Parkinson's syndrome, asthenic neuroses, neuroses with increased emotionality as well as chronic geriatric syndromes without foci. Out of a total of 113 patients, improvement under the action of royal jelly occurred in 71%, and in 13% there was a complete disappearance of symptoms.

A study whose results confirm the effect of royal jelly on the recovery of nerve cells was published in Yugoslavia at the first symposium in the field of veterinary science and practice, entitled "Influence of royal jelly on the morphogenesis of cortical neurons in rats of different ages". (Dragan Panić: Royal Jelly - Belgrade, 2000)